规格
Accession Number:	NP_940980.2
Assay Entry:	Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Ser⁄Thr Kinases: TKL Group
Shipping Condition:	Dry Ice
Target Entry:	LRRK2 D1994A
Target Gene:	LRRK2
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Catalytic
Protein Subtype:	Serine⁄Threonine Kinases
Research Category:	Signal Transduction, Neurobiology
Species:	Human
Validated Application:	Kinase Assay
Gene ID (Entrez):	120892
Molecular Weight:	205 kDa
Gene Alias:	LRRK2 D1994A
KinaseFamily:	LRRK Kinase Family
Protein Length:	aa 970-2527
Protein Tag:	GST Tag

储存
Kinase proteins are shipped on dry ice and should be stored at -80°C.

描述

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Certain mutations (e.g. I2020T, G2019S, and R1441C) in this gene have been associated with Parkinson's disease. D1994A is an artificial mutation that renders the kinase catalytically inactive and thus serves as a useful control for activity assays, especially when testing novel substrates.

Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® Activity Assay

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