规格
Accession Number:	AAH59394
Assay Entry:	Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical europium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Tyrosine Kinases
Mass:	10 µg
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Z'-LYTE™, Omnia® Bulk Substrate
Tag Position:	C-Terminal
Target Entry:	LYNB
Target Gene:	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Full Length, Recombinant, Cytoplasmic
Protein Subtype:	Cytoplasmic Tyrosine Kinases
Research Category:	Oncology, Signal Transduction
Species:	Human
Validated Application:	Kinase Assay
Gene ID (Entrez):	4067
Molecular Weight:	57.4 kDa
Gene Alias:	Lyn B
KinaseFamily:	SRC Kinase Family
Protein Tag:	His Tag

储存
Storage Buffer: 50 mM Tris, pH 7.5, 100 mM NaCl, 0.05 mM EDTA, 0.05% NP-40, 1 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

LYN is a SRC family kinase expressed predominantly in hematopoietic cells. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYNB and the slightly shorter LYNA are the two isoforms of LYN.

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