规格
Accession Number:	NP_000236.2, M1250T
Assay Entry:	Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Tyrosine Kinases
Mass:	10 µg
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position:	N-Terminal
Target Entry:	MET M1250T
Target Gene:	met proto-oncogene
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Recombinant, Cytoplasmic
Protein Subtype:	Receptor Tyrosine Kinases
Research Category:	Signal Transduction
Species:	Human
Validated Application:	Kinase Assay
Gene ID (Entrez):	4233, 4790
Molecular Weight:	53.7 kDa
Gene Alias:	MET M1250T
KinaseFamily:	MET (HGFR) Kinase Family
Protein Length:	aa 956-1390; M1250T
Protein Tag:	His Tag

储存
Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

MET (cMET) is a receptor-like tyrosine kinase whose disregulation has been linked to many types of human malignancies. The M1250T mutant of MET is both activating and displays altered substrate specificity.

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