Collagen III Antibody, anti-human, PE, REAdye_lease™，130-127-357，美天旎

Clone REAL912 is an antibody fragment derived from the full Collagen III antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL912 recognizes Collagen III, a fibrillar scleroprotein, is encoded by the COL3A1 gene. Collagen III consists of only one α collagen chain which forms a homotrimer containing three α1(III) chains and is secreted by fibroblasts and other mesenchymal cell types. It occurs in most extensible connective tissues e.g. in skin, lung, in the vascular system and in bone, cartilage, dentin, tendon, bone marrow and stroma. Collagen III is associated with type I collagen, which are the major components of the interstitial matrix. Collagen III plays a role in the regulation of cortical development. Genomic mutations of COL3A1 lead to different types of Ehlers-Danlos syndrome or aortic aneurysm abdominal (AAA).

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675)

Collagen 3, COL3A1

Technical specifications