CD279 (PD1) Antibody, anti-human, Vio® R667, REAfinity™，130-131-145，美天旎

Clone REA1165 recognizes the human CD279 antigen, also known as programmed death-1 (PD-1) or PD1. CD279 is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, activated myeloid cells, and dendritic cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (CD274, also knwon as B7-H1) and PD-L2 (CD273, also known as B7-DC) belong to the B7 immunglobulin superfamily. PD-1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology.

Additional information: Clone REA1165 displays negligible binding to Fc receptors.

PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1

Technical specifications