规格
Accession Number:	NP_004324.1, V599E
Assay Entry:	Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Ser⁄Thr Kinases: TKL Group
Mass:	10 µg
Protein Form:	Recombinant, Catalytic
Research Category:	Oncology, Signal Transduction
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™
Tag Position:	N-Terminal
Target Entry:	BRAF V599E
Target Gene:	v-raf murine sarcoma viral oncogene homolog B1
Gene ID (Entrez):	10488, 673
Molecular Weight:	67.1 kDa
Protein Subtype:	Serine⁄Threonine Kinases
Gene Alias:	BRAF V599E
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	RAF Kinase Family
Protein Length:	aa 416-766
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of cancers.

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