NGF-β stands for nerve growth factor β. Human NGF-β is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human NGF-β can be used for a variety of applications, including:

Neuronal proliferation and differentiation.
Induction of axonal growth.
Proliferation of stem Leydig cells.

Biological activity

Background information

Nerve growth factor β (NGF-β) is the first identified member of the NGF family, also known as neurotrophins, which is characterized by a homodimeric cystine knot structure, and includes also brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). The precursor of NGF-β, pro-NGF-β, is biologically inactive and it is cleaved to generate the mature form. NGF-β acts as a potent neurotrophic factor via binding of two classes of receptors, which activate a complex intracellular cascade. NGF-β plays a central role in the sensory and sympathetic nervous system, supports the growth and maintenance of nerve and glial cells, and induces axonal growth. Besides its role in the nervous system, NGF-β can also induce differentiation and survival of B cells. NGF-β and its receptors have been associated with several psychiatric and neurodegenerative disorders, such as Alzheimer disease and multiple sclerosis. The protein sequences of human and mouse NGF-β share 90% identity and exhibit cross species activity.

Quality description

Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

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