规格
Accession Number:	NM_000115.1
Assay Entry:	Cell-based beta lactamase reporter gene
Cell Line:	293T (HEK)
Cell State:	Dividing Cells
Druggable Target:	GPCRs
Gene Symbol:	EDNRB
Population Status:	Single Cell Clone Origin
Product Line:	GeneBLAzer®
Reporter Gene:	BLA (Beta-Lactamase)
System Type:	GeneBLAzer™
Target Entry:	EDNRB
Technique:	FRET
Detection Method:	Fluorescent

储存

Contents:
K1727 GeneBLAzer® EDNRB-NFAT-bla HEK293T cells
(LiveBLAzer™-FRET B⁄G Loading Kit, Solution D and other materials are required separately; please refer to the protocol).
Includes:
• GeneBLAzer® EDNRB-NFAT-bla HEK293T cells
• GeneBLAzer® EDNRB-NFAT-bla HEK293T Assay Protocol
• Certificate of Analysis

Storage:
The GeneBLAzer® GeneBLAzer® EDNRB-NFAT-bla HEK293T cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.

描述

GeneBLAzer® EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor® NFAT-bla HEK293T cell line. CellSensor® NFAT-bla HEK293T cells (Cat. no. K1538) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer® EDNRB-NFAT-bla HEK293T cells are functionally validated for Z' and EC₅₀ concentrations of ET-1. In addition, GeneBLAzer® EDNRB-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The ENDRB receptor mediates signaling of endothelin proteins that regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division. Defects in EDNRB mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension and cardiovascular disorders.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

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