规格
Accession Number:	NP_005219.2; T790M L858R
Assay Entry:	Biochemical binding/kinetic
Kinase Group:	Tyrosine Kinases
Protein Form:	Recombinant, Cytoplasmic
Research Category:	Oncology, Signal Transduction
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	Z'-LYTE™
Target Entry:	EGFR T790M L858R
Target Gene:	Epidermal growth factor receptor
Gene ID (Entrez):	1956
Molecular Weight:	90.6 kDa
Protein Subtype:	Receptor Tyrosine Kinases
Gene Alias:	EGFR (ErbB1) T790M L858R
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	EGF Receptor (ErbB) Kinase Family
Protein Length:	aa 668-1210; T790M, L858R
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.

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