规格
Accession Number:	NP_006242.4 I NP_006244.2 I NP_002724.1
Assay Entry:	Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Ser⁄Thr Kinases: CAMK Group
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Z'-LYTE™, Omnia® Bulk Substrate
Tag Position:	GST (N-Terminal)⁄GST (N-Terminal)⁄His (N-Terminal)
Target Entry:	AMPK (A1/B1/G1)
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Full Length, Recombinant
Protein Subtype:	Serine⁄Threonine Kinases
Research Category:	Signal Transduction
Species:	Human
Validated Application:	Kinase Assay
Molecular Weight:	90.8/ 57.8/ 41.7 kDa
Gene Alias:	AMPK A1/B1/G1
KinaseFamily:	CAMKL Kinase Family
Protein Tag:	GST Tag, His Tag

储存
Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.02% Triton X-100, 0.5 mM EDTA, 2 mM DTT, 50% Glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

AMP-activated protein kinase (AMPK) is a heterotrimeric complex that acts as sensor of cellular energy levels. The signaling cascades initiated by activating AMPK are critical to regulating metabolic events in the liver, skeletal muscle, heart, adipose tissue, and pancreas. An impairment in fuel metabolism that occurs in obesity is a factor leading to type 2 diabetes. The insulin resistance associated with type 2 diabetes is most profound at the level of skeletal muscle, the primary site of glucose and fatty acid utilization. Activation of AMPK is of interest for the treatment of type 2 diabetes.

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