Granzyme A Antibody, anti-human, APC, REAdye_lease™，130-127-667，美天旎

Clone REAL1084 is an antibody fragment derived from the full Granzyme A antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1084 recognizes Granzyme A, a member of the serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include to facilitate the migration of T and NK cells and induction of cytokine secretion.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

GZMA, Fragmentin-1, Granzyme-1, Hanukkah factor, HF, H factor, CTL tryptase, Cytotoxic T-lymphocyte proteinase 1

Technical specifications