Interleukin 15 (IL-15) is a potent lymphoid cell growth factor and stimulates the proliferation of activated T cells and the generation of cytotoxic T lymphocytes (CTLs). IL-15 also induces the generation, activation, and proliferation of NK cells.

MACS GMP Recombinant Human IL-15 is designed for ex vivo cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives.

Biological activity

Background information

IL-15 is a member of the four α-helix bundle cytokine family. It is produced by different cell types, including epithelial cells, monocytes, muscle and placenta cells. In addition to its ability to activate T cells and NK cells, IL-15 is also important for B cell growth and immunoglobulin production as well as for the maintenance of CD8⁺ memory T cells. For binding and signaling IL-15 uses the unique IL-15 receptor α-chain, but shares the β- and γ-chain of the IL-2 receptor.

Applications

MACS GMP Recombinant Human IL-15 can be used for a variety of applications, including the ex vivo generation of cytotoxic T lymphocytes²^,3 or the ex vivo stimulation of NK cells⁴^,5.

Technical specifications

Identity/ Molecular mass: 12.770 Da, determined by mass spectrometry. This corresponds to the mature form of human IL-15 (114 amino acids).
Purity: ≥ 95 % as determined by chip electrophoresis.
Product related impurities: ≤ 10 % as determined by chip electrophoresis.
Endotoxin content: < 100 EU/mg, as determined by kinetic Limulus Amoebocyte Lysate (LAL) assay (Pharmacopoeia Europaea (Ph. Eur.)).
Residual host cell DNA content: < 20 ng/mg, as determined by quantitative PCR specific for E. coli genomic DNA.
Residual host cell protein content: < 10 µg/mg, as determined by E. coli HCP ELISA.

The product quality certificate of MACS^® GMP Recombinant Human IL-15 was adapted. Learn more here

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Disclaimer

MACS GMP Products are for ex vivo cell processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.

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