- 商品介绍
- 规格参数
- 包装参数
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规格 |
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| Accession Number: | NP_036530.1 |
| Protein Form: | Full Length, Recombinant, Active |
| Shipping Condition: | Dry Ice |
| Molecular Weight: | 99.6 kDa |
| Validated Application: | Kinase Assay |
| Expression System: | Insect |
| KinaseFamily: | PI3 Kinase |
| Protein Length: | Full Length |
| Protein Tag: | GST Tag |
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储存 |
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| Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol |
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描述 |
This PIP5K1C recombinant human protein (full length) was expressed in insect cells. PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with β-catenin and increases β-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance β-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemoattractants. PIP5K1C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Adapta™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
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¥ 56581.65
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¥ 66363.43
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