规格
Accession Number:	NP_002341.1
Expression System:	Insect
Protein Form:	Full Length
Research Category:	Drug Development
Species:	Human
Validated Application:	Kinase Assay
Molecular Weight:	81 kDa
Gene Alias:	JTK8, FLJ26625
KinaseFamily:	SRC Kinase Family
Protein Tag:	GST Tag

储存
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase. Suspended in: 50 nM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

描述

LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a SRC family kinase expressed predominantly in hematopoietic, neural, liver, and adipose tissue. It is a protein-coding gene and is associated with diseases such as alexia and chorea-acanthocytosis. Activation of LYN has been shown to lead to imatinib resistance in CML patients. LYN B and the slightly shorter LYN A are the two isoforms of LYN. An important paralog of this gene is FRK. The full length LYN A protein enables researchers to study important mechanisms underlying disease.

• Increase disease relevance by interrogating a purified and active full-length LYN A reagent
• Uncover novel compounds or hits specific to the full length form
• Advance your research using the full-length protein and validated assays

Assay Platforms:
LanthaScreen® TR-FRET Kinase Activity Assay
LanthaScreen® Eu Kinase Binding Assay
Z’-LYTE™ Kinase Activity Assay

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