规格
Accession Number:	NP_005017.3, NP_852664.1
Product Line:	Life Technologies™
Protein Form:	Full Length
Research Category:	Drug Development
Shipping Condition:	Dry Ice
Species:	Human
Gene ID (Entrez):	5293, 5295
Molecular Weight:	84.7 kDa, 120.6 kDa
Quantity:	20μg
Gene Alias:	p110 delta/p85 alpha, phosphoinositide-3-kinase, p110δ/p85α, regulatory subunit 1 (alpha)
Gene Symbol:	PIK3CD, PIK3R1
Validated Application:	Kinase Assay
Expression System:	Baculovirus
KinaseFamily:	PI3 Kinase Family
Protein Tag:	His Tag

储存
Storage buffer: 50 mM sodium phosphate (pH 7.0), 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol. Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

Phosphatidylinositol 3-kinase (PI3K) is composed of a catalytic subunit (p110δ) and a regulatory subunit (p85α in this case), which are encoded by the PIK3CD and PIK3R1 genes. PI3K phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It plays a role in oncogenic transformation and is consistently expressed at a high level in AML blast cells. PI3K can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that leads to neutrophil polarization, and regulates directional migration, but not random locomotion. The PI3K signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.

PIK3CD/PIK3R1 (p110δ/p85α) recombinant human protein is:
• Available in 3 convenient sizes
• Validated in our Adapta™ and Kinase Binding assays
• A full length protein that can help advance your research when used with validated assays

Related assay platforms:
LanthaScreen® Kinase Binding Assay
Adapta® Kinase Activity Assay

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