Clone REAL1088 is an antibody fragment derived from the full STING (TMEM173) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.

Clone REAL1088 recognizes the human STING protein, also known as MITA and ERIS and is encoded by the TMEM173 gene. STING is essential for controlling the transcription of numerous host defence genes, including IFNs, Cytokins and CDNs and function as adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Polymorphisms in TMEM173 have been reported to influence STING-dependent innate immune signalling and might affect susceptibility to pathogen infection and contribute to severe inflammatory disorders. STING signalling has now been shown to be essential for protecting the cell against a variety of pathogens and the development of cancer by promoting anti tumor immune responses.

For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Stimulator of interferon genes protein, STING, ERIS, MITA, TMEM173

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