CD192 (CCR2)-Biotin, mouse, REA538, 100t，130-128-939，美天旎

Clone REA538 recognizes the mouse CD192 antigen, a multi-pass membrane protein, which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). CD192 is a receptor for the CCL2, CCL7, and CCL12 chemokines and plays important roles in the recruitment of monocytes, macrophages, and T cells. It transduces a signal by increasing intracellular calcium ion levels. In mice CD192 is homogeneously expressed on monocytes and on 2–15% of T cells, closely resembling the expression pattern in humans. The percentage of CD192⁺ T cells is almost two times higher in the Tʜ1-prone mouse strain C57BL/6 than in the Tʜ2-prone strain BALB/c. The strain-dependent expression correlates to a reduced Tʜ1 response described in CD192-deficient mice.

Additional information: Clone REA538 displays negligible binding to Fc receptors.

CCR2, CC-CKR-2, CCR2B, Ckr2, CKR2A, Ckr2b, Cmkbr2, mJe-r, MCP-1-R

Technical specifications