规格
Accession Number:	NP_006210.1, NP_852664.1
Shipping Condition:	Dry Ice
Expression System:	Baculovirus
Protein Form:	Full Length, Recombinant, Active
Research Category:	Signal Transduction, Drug Development, Oncology
Species:	Human
Validated Application:	Kinase Assay
Gene ID (Entrez):	PIK3R1, PIK3CB
Molecular Weight:	123.7 kDa, 84.7 kDa
Gene Alias:	phosphatidylinositol-4, 5-bisphosphate 3-kinase, p110 beta/p85 alpha, p110β/p85α
KinaseFamily:	PI3 Kinase
Protein Tag:	His Tag

储存
Storage buffer: 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol. Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively. As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.

PIK3CB/PIK3R1 (p110β/p85α) Recombinant Human Protein is:
• Available in 3 convenient sizes
• Validated in our Adapta® and Kinase Binding assays
• A full-length protein that can help advance your research when used in validated assays

Related assay platforms:
LanthaScreen® Kinase Binding Assay
Adapta® Kinase Activity Assay

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