规格
Accession Number:	NP_055124, Y791F
Assay Entry:	Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Tyrosine Kinases
Mass:	10 µg
Shipping Condition:	Dry Ice
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™, Omnia® Bulk Substrate
Tag Position:	N-Terminal
Target Entry:	RET Y791F
Target Gene:	ret proto-oncogene
Expression System:	Baculovirus
Protein Family:	Kinases & Inhibitors
Protein Form:	Recombinant, Cytoplasmic
Protein Subtype:	Receptor Tyrosine Kinases
Research Category:	Oncology, Signal Transduction
Species:	Human
Validated Application:	Kinase Assay
Molecular Weight:	79.0 kDa
Gene Alias:	RET Y791F
KinaseFamily:	RET Kinase Family
Protein Length:	aa 658-1114; Y791F
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton X-100, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development, and can undergo oncogenic activation by cytogenetic rearrangement. The Y791F mutant has been observed clinical in association with cancer.

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