GITRL Antibody, anti-human, Vio® Bright V423, REAfinity™，130-128-531，美天旎

Clone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses.

Additional information: Clone REA841 displays negligible binding to Fc receptors.

hGITRL, GITR Ligand, GITR-L, AITR Ligand, AITRL, AITR-L, TL6, TNFSF18

Technical specifications