CITRACONIC ANHYDRIDE, 100 G EA，20907，赛默飞世尔

Thermo Scientific Pierce Citraconic Anhydride reacts with primary amines to to form an amide bond with a terminal carboxyl group. This modification can be reversed using acidic conditions (pH 3-4) or with hydroxylamine.

Citraconic Anhydride (2-methylmaleic anhydride) is used to block primary amine groups at alkaline pH values (pH 7-9). At acidic pH (3-4), the amide linkage is hydrolyzed and citraconic acid is released, revealing the original amine.

Features of Citraconic Anhydride:

• Temporarily block amines to derivatize other parts of the molecule
• Unblock amines using acidic conditions or hydroxylamine