CD59a Antibody, anti-mouse, PE, REAfinity™，130-130-181，美天旎

Clone REA287 recognizes the CD59a antigen, the murine analog of human CD59 which is also known as MAC-inhibitory protein (MAC-IP) or membrane attack complex inhibition factor (MACIF). CD59a is widely distributed, being present on all circulating cells, epithelia, and endothelia and in most tissues examined. CD59a blocks the formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex, hereby protecting the cells from complement-mediated lysis. Further, CD59a down-modulates CD4⁺ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.

Additional information: Clone REA287 displays negligible binding to Fc receptors.

MAC-inhibitory protein (MAC-IP), Membrane attack complex inhibition factor (MACIF), Protectin, CD59

Technical specifications