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0BF2371
- AV974024-50ug
- Anti-Avelumab Polyclonal Antibody,50ug,AV974024-50ug,Abinscience
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- ¥ 2108.00
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0BF2371
| Host species | Rabbit |
| Species reactivity | |
| Immunogen | Avelumab |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Applications | ELISA |
| Target | Rabbit polyclonal to Bavencio. |
| Purification | Purified by antigen affinity column. |
| Stability and Storage | The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles. |
| Background | Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as "immune checkpoint inhibition. |
| Alternative Names | |
| Note | Antibodysystem can customize this product per customer's request including product size, buffer components, etc. For research use only. |
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